Lipid excipients are applied for numerous purposes\nsuch as taste masking, controlled release, improvement of\nswallowability and moisture protection. Several melting techniques\nhave evolved in the last decades. Common examples\nare melt coating, melt granulation and melt extrusion. The required\nequipment ranges from ordinary glass beakers for lab scale\nup to large machines such as fluid bed coaters, spray dryers or\nextruders. This allows for upscaling to pilot or production scale.\nSolvent free melt processing provides a cost-effective, time-saving\nand eco-friendly method for the food and pharmaceutical industries.\nThis review intends to give a critical overview of the published\nliterature on experiences, formulations and challenges and\nto show possibilities for future developments in this promising\nfield. Moreover, it should serve as a guide for selecting the best\nexcipients and manufacturing techniques for the development of a\nproduct with specific properties using solvent free melt\nprocessing.
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